Ontology highlight
ABSTRACT:
SUBMITTER: Thomas RR
PROVIDER: S-EPMC3005536 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Mitochondrion 20100818 1
Recombinant human mitochondrial transcription factor A protein (rhTFAM) was evaluated for its acute effects on cultured cells and chronic effects in mice. Fibroblasts incubated with rhTFAM acutely increased respiration in a chloramphenicol-sensitive manner. SH-SY5Y cells showed rhTFAM concentration-dependent reduction of methylpyridinium (MPP(+))-induced oxidative stress and increases in lowered ATP levels and viability. Mice treated with weekly i.v. rhTFAM showed increased mitochondrial gene co ...[more]