Recombinant human mitochondrial transcription factor A stimulates mitochondrial biogenesis and ATP synthesis, improves motor function after MPTP, reduces oxidative stress and increases survival after endotoxin.
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ABSTRACT:
SUBMITTER: Thomas RR
PROVIDER: S-EPMC3005536 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
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Recombinant human mitochondrial transcription factor A stimulates mitochondrial biogenesis and ATP synthesis, improves motor function after MPTP, reduces oxidative stress and increases survival after endotoxin.
Thomas Ravindar R RR Khan Shaharyar M SM Portell Francisco R FR Smigrodzki Rafal M RM Bennett James P JP
Mitochondrion 20100818 1
Recombinant human mitochondrial transcription factor A protein (rhTFAM) was evaluated for its acute effects on cultured cells and chronic effects in mice. Fibroblasts incubated with rhTFAM acutely increased respiration in a chloramphenicol-sensitive manner. SH-SY5Y cells showed rhTFAM concentration-dependent reduction of methylpyridinium (MPP(+))-induced oxidative stress and increases in lowered ATP levels and viability. Mice treated with weekly i.v. rhTFAM showed increased mitochondrial gene co ...[more]
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