Ontology highlight
ABSTRACT:
SUBMITTER: Rebeiz M
PROVIDER: S-EPMC3005598 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Rebeiz Mark M Miller Steven W SW Posakony James W JW
Development (Cambridge, England) 20101209 2
The Notch cell-cell signaling pathway is used extensively in cell fate specification during metazoan development. In many cell lineages, the conditional role of Notch signaling is integrated with the autonomous action of the Numb protein, a Notch pathway antagonist. During Drosophila sensory bristle development, precursor cells segregate Numb asymmetrically to one of their progeny cells, rendering it unresponsive to reciprocal Notch signaling between the two daughters. This ensures that one daug ...[more]