Ontology highlight
ABSTRACT:
SUBMITTER: Li D
PROVIDER: S-EPMC3005605 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Li Deqiang D Hallett Mark A MA Zhu Wuqiang W Rubart Michael M Liu Ying Y Yang Zhenyun Z Chen Hanying H Haneline Laura S LS Chan Rebecca J RJ Schwartz Robert J RJ Field Loren J LJ Atkinson Simon J SJ Shou Weinian W
Development (Cambridge, England) 20110101 2
Dishevelled-associated activator of morphogenesis 1 (Daam1), a member of the formin protein family, plays an important role in regulating the actin cytoskeleton via mediation of linear actin assembly. Previous functional studies of Daam1 in lower species suggest its essential role in Drosophila trachea formation and Xenopus gastrulation. However, its in vivo physiological function in mammalian systems is largely unknown. We have generated Daam1-deficient mice via gene-trap technology and found t ...[more]