Ontology highlight
ABSTRACT:
SUBMITTER: Pible O
PROVIDER: S-EPMC3005792 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Pible Olivier O Vidaud Claude C Plantevin Sophie S Pellequer Jean-Luc JL Quéméneur Eric E
Protein science : a publication of the Protein Society 20101101 11
The uranyl cation (UO(2) (2+)) can be suspected to interfere with the binding of essential metal cations to proteins, underlying some mechanisms of toxicity. A dedicated computational screen was used to identify UO(2) (2+) binding sites within a set of nonredundant protein structures. The list of potential targets was compared to data from a small molecules interaction database to pinpoint specific examples where UO(2) (2+) should be able to bind in the vicinity of an essential cation, and would ...[more]