Ontology highlight
ABSTRACT:
SUBMITTER: Goldsbury C
PROVIDER: S-EPMC3005892 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Goldsbury Claire C Baxa Ulrich U Simon Martha N MN Steven Alasdair C AC Engel Andreas A Wall Joseph S JS Aebi Ueli U Müller Shirley A SA
Journal of structural biology 20100922 1
Amyloid fibrils are filamentous protein aggregates implicated in several common diseases such as Alzheimer's disease and type II diabetes. Similar structures are also the molecular principle of the infectious spongiform encephalopathies such as Creutzfeldt-Jakob disease in humans, scrapie in sheep, and of the so-called yeast prions, inherited non-chromosomal elements found in yeast and fungi. Scanning transmission electron microscopy (STEM) is often used to delineate the assembly mechanism and s ...[more]