Colorectal cancer molecular biology moves into clinical practice.
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ABSTRACT:
SUBMITTER: Pritchard CC
PROVIDER: S-EPMC3006043 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Publications
Colorectal cancer molecular biology moves into clinical practice.
Pritchard Colin C CC Grady William M WM
Gut 20101004 1
The promise of personalised medicine is now a clinical reality, with colorectal cancer genetics at the forefront of this next major advance in clinical medicine. This is no more evident than in the recent advances in testing of colorectal cancers for specific molecular alterations in order to guide treatment with the monoclonal antibody therapies cetuximab and panitumumab, which target the epidermal growth factor receptor. In this review, genetic mechanisms of colorectal cancer and how these alt ...[more]
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