Ontology highlight
ABSTRACT:
SUBMITTER: Johnston AP
PROVIDER: S-EPMC3006204 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Johnston Adam P W AP Baker Jeff J Bellamy Leeann M LM McKay Bryon R BR De Lisio Michael M Parise Gianni G
PloS one 20101221 12
The role of angiotensin II (Ang II) in skeletal muscle is poorly understood. We report that pharmacological inhibition of Ang II signaling or ablation of the AT1a receptor significantly impaired skeletal muscle growth following myotrauma, in vivo, likely due to impaired satellite cell activation and chemotaxis. In vitro experiments demonstrated that Ang II treatment activated quiescent myoblasts as evidenced by the upregulation of myogenic regulatory factors, increased number of β-gal+, Myf5-Lac ...[more]