PEG-based hydrogels with collagen mimetic peptide-mediated and tunable physical cross-links.
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ABSTRACT:
SUBMITTER: Stahl PJ
PROVIDER: S-EPMC3006224 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Publications
PEG-based hydrogels with collagen mimetic peptide-mediated and tunable physical cross-links.
Stahl Patrick J PJ Romano Nicole H NH Wirtz Denis D Yu S Michael SM
Biomacromolecules 20100901 9
Mechanical properties of tissue scaffolds have major effects on the morphology and differentiation of cells. In contrast to two-dimensional substrates, local biochemical and mechanical properties of three-dimensional hydrogels are difficult to control due to the geometrical confinement. We designed synthetic 3D hydrogels featuring complexes of four-arm poly(ethylene glycol) (PEG) and collagen mimetic peptides (CMPs) that form hydrogels via physical cross-links mediated by thermally reversible tr ...[more]
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