Ontology highlight
ABSTRACT:
SUBMITTER: Savage DF
PROVIDER: S-EPMC300682 | biostudies-literature | 2003 Dec
REPOSITORIES: biostudies-literature
Savage David F DF Egea Pascal F PF Robles-Colmenares Yaneth Y O'Connell Joseph D JD Stroud Robert M RM
PLoS biology 20031222 3
Aquaporins are a family of water and small molecule channels found in organisms ranging from bacteria to animals. One of these channels, the E. coli protein aquaporin Z (AqpZ), has been shown to selectively conduct only water at high rates. We have expressed, purified, crystallized, and solved the X-ray structure of AqpZ. The 2.5 A resolution structure of AqpZ suggests aquaporin selectivity results both from a steric mechanism due to pore size and from specific amino acid substitutions that regu ...[more]