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N'-[(E)-1-(5-Chloro-2-hy-droxy-phen-yl)ethyl-idene]pyridine-3-carbohydrazide monohydrate.

ABSTRACT: In the title compound, C(14)H(12)ClN(3)O(2)·H(2)O, the benzene ring and the pyridine rings are oriented at a dihedral angle of 57.73 (12)° and an intra-molecular O-H⋯N hydrogen bond generates an S(6) ring. In the crystal, the water mol-ecule forms O-H⋯O and O-H⋯N hydrogen bonds to the organic mol-ecule, leading to chains containing R(4) (4)(16) loops. In addition, weak aromatic π-π stacking inter-actions between the centroids of pyridine rings [at distance of 3.864 (2) and 4.013 (2) Å] and C-H⋯π inter-actions occur.

SUBMITTER: Hussain A

PROVIDER: S-EPMC3006986 | biostudies-literature |

REPOSITORIES: biostudies-literature

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N'-[1-(2-Hy-droxy-phen-yl)ethyl-idene]thio-phene-2-carbohydrazide.

Project description:The title compound, C(13)H(12)N(2)O(2)S, was prepared by the reaction of 1-(2-hy-droxy-phen-yl)ethanone and thio-phene-2-carbohydrazide. The dihedral angle between the benzene and thio-phene rings is 10.07?(17)°. An intra-molecular O-H?N hydrogen bond may influence the mol-ecular conformation. In the crystal, mol-ecules are linked by N-H?O hydrogen bonds into chains along [010].

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N'-[(E)-1-(2-Hy-droxy-phen-yl)ethyl-idene]pyrazine-2-carbohydrazide.

Project description:The title compound, C13H12N4O2, crystallized with two independent mol-ecules (A and B) in the asymmetric unit. Mol-ecule B is planar to within 0.044?(3)?Å for all non-H atoms, while mol-ecule A is slightly twisted, with a dihedral angle of 6.29?(4)° between the mean planes of the pyrazine-2-carbohydrazide and 1-(2-hy-droxy-phen-yl)ethanone moieties (r.m.s. deviations = 0.0348 and 0.0428?Å, respectively). S(5) and S(6) ring motifs are formed in both mol-ecules due to the presence of intra-molecular O-H?N and N-H?N hydrogen bonds. In the crystal, mol-ecules A and B are linked by a C-H?O hydrogen bond. They stack along the a-axis direction, forming columns with ?-? inter-actions involving inversion-related pyrazine and benzene rings [centroid-centroid distances = 3.5489?(13)-3.8513?(16)?Å].

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2-Cyano-N'-[1-(2-hy-droxy-phen-yl)ethyl-idene]acetohydrazide monohydrate.

Project description:The title compound, C(11)H(11)N(3)O(2)·H(2)O, was obtained by the reaction of 2-acetyl-phenol with cyano-acetohydrazide in methanol. The asymmetric unit contains two hydrazone mol-ecules and two water mol-ecules of crystallization. There is an intra-molecular O-H⋯N hydrogen bond in each hydrazone mol-ecule. The crystal structure is stabilized by inter-molecular N-H⋯O, O-H⋯O and O-H⋯N hydrogen bonds.

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2-Hy-droxy-ethyl-ammonium [2-(2,6-di-chloro-anilino)phen-yl]acetate monohydrate.

Project description:In the solid-state structure of the title compound derived from diclofenac, C2H8NO+·C14H10Cl2NO2 -·H2O, the asymmetric unit contains one cation, one anion and a water mol-ecule, all in general positions. A complex network of hydrogen bonds is present in the crystal structure.

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N'-[(E)-2-Hy-droxy-5-meth-oxy-benzyl-idene]pyridine-4-carbohydrazide monohydrate.

Project description:The title compound, C14H13N3O3·H2O, adopts an E conformation with respect to the azomethine bond and crystallizes in the amide form. An intra-molecular O-H⋯N hydrogen bond occurs. In the crystal, the lattice water molecule plays a major role in the supramolecular architecture by interconnecting adjacent molecules into a three-dimensional netwrok by means of O-H⋯O, O-H⋯N and N-H⋯O hydrogen-bonding inter-actions. The structure also features two non-classical C-H⋯O inter-actions.

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4-Hy-droxy-N'-[1-(2-hy-droxy-phen-yl)ethyl-idene]benzohydrazide.

Project description:In the title compound, C(15)H(14)N(2)O(3), there is an intra-molecular O-H?N hydrogen bond and the dihedral angle between the two aromatic rings is 13.9?(3)°. In the crystal structure, mol-ecules are stabilized by inter-molecular O-H?O and N-H?O hydrogen bonds.

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N'-[(E)-1-(5-Bromo-2-hy-droxy-phen-yl)ethyl-idene]-2-chloro-benzohydrazide.

Project description:The title compound, C(15)H(12)BrClN(2)O(2), was synthesized by the condensation of 1-(5-bromo-2-hy-droxy-phen-yl)ethanone with 2-chloro-benzohydrazide in anhydrous ethanol. The Schiff base mol-ecule displays a trans configuration with respect to the C=N double bond. The dihedral angle between the two benzene rings is 13.74 (3)°. The mol-ecular conformation is stabilized by an intra-molecular O-H⋯N and the crystal structure by inter-molecular N-H⋯O hydrogen bonds.

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N'-[(E)-1-(2-Fluoro-phen-yl)ethyl-idene]pyridine-4-carbohydrazide.

Project description:The title compound, C14H12FN3O, adopts an E conformation with respect to the azomethine bond. The pyridyl and fluoro-benzene rings make dihedral angles of 38.58?(6) and 41.61?(5)° respectively with the central C(=O)N2CC unit, resulting in a non-planar mol-ecule. The inter-molecular inter-actions comprise two classical N-H?O and N-H?N hydrogen bonds and four non-classical C-H?O and C-H?F hydrogen bonds. These inter-actions are augmented by a weak ?-? inter-action between the benzene and pyridyl rings of neighbouring mol-ecules, with a centroid-centroid distance of 3.9226?(10)?Å. This leads to a three-dimensional supra-molecular assembly in the crystal system. The F atom is disordered over two sites in a 0.559?(3): 0.441?(3) ratio, through a 180° rotation of the fluoro-benzene ring.

| S-EPMC4011257 | biostudies-literature

N'-[(1E)-1-(2-Fluoro-phen-yl)ethyl-idene]pyridine-3-carbohydrazide.

Project description:The title compound, C14H12FN3O, adopts an E conformation with respect to the azomethine double bond whereas the N and methyl C atoms are in a Z conformation with respect to the same bond. The ketonic O and azomethine N atoms are cis to each other. The non-planar mol-ecule [the dihedral angle between the benzene rings is 7.44 (11)°] exists in an amido form with a C=O bond length of 1.221 (2) Å. In the crystal, a bifurcated N-H⋯(O,N) hydrogen bond is formed between the amide H atom and the keto O and imine N atoms of an adjacent mol-ecule, leading to the formation of chains propagating along the b-axis direction. Through a 180° rotation of the fluoro-phenyl ring, the F atom is disordered over two sites with an occupancy ratio of 0.632 (4):0.368 (4).

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{5-Chloro-2-[(2-hy-droxy-benzyl-idene)amino]-phen-yl}(phen-yl)methanone.

Project description:The title Schiff base compound, C(20)H(14)ClNO(2), adopts an E configuration about the azomethine bond. The phenol and chloro-benzene rings form dihedral angles of 84.71?(9) and 80.70?(8)°, respectively, with the phenyl ring and are twisted by 15.32?(8)° with respect to one another. The mol-ecular conformation is stabilized by an intra-molecular O-H?N hydrogen bond, which forms an S(6) ring motif. In the crystal, mol-ecules are linked by C-H?O hydrogen bonds, forming columns parallel to the a axis.

| S-EPMC3239075 | biostudies-literature

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