Ontology highlight
ABSTRACT:
SUBMITTER: Salek-Ardakani S
PROVIDER: S-EPMC3007137 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Salek-Ardakani Shahram S Flynn Rachel R Arens Ramon R Yagita Hideo H Smith Geoffrey L GL Borst Jannie J Schoenberger Stephen P SP Croft Michael M
The Journal of clinical investigation 20101222 1
Induction of CD8+ T cell immunity is a key characteristic of an effective vaccine. For safety reasons, human vaccination strategies largely use attenuated nonreplicating or weakly replicating poxvirus-based vectors, but these often elicit poor CD8+ T cell immunity and might not result in optimal protection. Recent studies have suggested that virulence is directly linked to immunogenicity, but the molecular mechanisms underlying optimal CD8+ T cell responses remain to be defined. Here, using natu ...[more]