Ontology highlight
ABSTRACT:
SUBMITTER: Beauchamp EM
PROVIDER: S-EPMC3007144 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Beauchamp Elspeth M EM Ringer Lymor L Bulut Gülay G Sajwan Kamal P KP Hall Michael D MD Lee Yi-Chien YC Peaceman Daniel D Ozdemirli Metin M Rodriguez Olga O Macdonald Tobey J TJ Albanese Chris C Toretsky Jeffrey A JA Uren Aykut A
The Journal of clinical investigation 20101222 1
The Hedgehog (Hh) pathway is activated in some human cancers, including medulloblastoma. The glioma-associated oncogene homolog (GLI) transcription factors are critical mediators of the activated Hh pathway, and their expression may be elevated in some tumors independent of upstream Hh signaling. Thus, therapies targeting GLI transcription factors may benefit a wide spectrum of patients with mutations at different nodal points of the Hh pathway. In this study, we present evidence that arsenic tr ...[more]