Ontology highlight
ABSTRACT:
SUBMITTER: Bailey CG
PROVIDER: S-EPMC3007158 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Bailey Charles G CG Ryan Renae M RM Thoeng Annora D AD Ng Cynthia C King Kara K Vanslambrouck Jessica M JM Auray-Blais Christiane C Vandenberg Robert J RJ Bröer Stefan S Rasko John E J JE
The Journal of clinical investigation 20101201 1
Solute carrier family 1, member 1 (SLC1A1; also known as EAAT3 and EAAC1) is the major epithelial transporter of glutamate and aspartate in the kidneys and intestines of rodents. Within the brain, SLC1A1 serves as the predominant neuronal glutamate transporter and buffers the synaptic release of the excitatory neurotransmitter glutamate within the interneuronal synaptic cleft. Recent studies have also revealed that polymorphisms in SLC1A1 are associated with obsessive-compulsive disorder (OCD) i ...[more]