Ontology highlight
ABSTRACT:
SUBMITTER: Bishop MW
PROVIDER: S-EPMC3007632 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Bishop Matthew W MW Chakraborty Subhojit S Matthews Gillian A C GA Dougalis Antonios A Wood Nicholas W NW Festenstein Richard R Ungless Mark A MA
Journal of neurophysiology 20101006 6
The electrophysiological properties of substantia nigra pars compacta (SNC) dopamine neurons can influence their susceptibility to degeneration in toxin-based models of Parkinson's disease (PD), suggesting that excitotoxic and/or hypoactive mechanisms may be engaged during the early stages of the disease. It is unclear, however, whether the electrophysiological properties of SNC dopamine neurons are affected by genetic susceptibility to PD. Here we show that deletion of PD-associated genes, PINK ...[more]