CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice.
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ABSTRACT:
SUBMITTER: Gorantla S
PROVIDER: S-EPMC3008566 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Publications
CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice.
Gorantla Santhi S Makarov Edward E Finke-Dwyer Jennifer J Gebhart Catherine L CL Domm William W Dewhurst Stephen S Gendelman Howard E HE Poluektova Larisa Y LY
Journal of immunology (Baltimore, Md. : 1950) 20100521 12
Stable engraftment of human lymphoid tissue in NOD/scid-IL-2Rgammacnull mice after CD34+ hematopoietic stem cell reconstitution permits the evaluation of ongoing HIV-1 infection for weeks to months. We demonstrate that HIV-1-infected rodents develop virus-specific cellular immune responses. CD8+ cell depletion, 2 or 5-7 wk after viral infection, resulted in a significant increase of HIV-1 load, robust immune cell activation, and cytopathology in lymphoid tissues but preserved CD4/CD8 double-posi ...[more]
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