Ontology highlight
ABSTRACT:
SUBMITTER: Cattoglio C
PROVIDER: S-EPMC3008730 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Cattoglio Claudia C Maruggi Giulietta G Bartholomae Cynthia C Malani Nirav N Pellin Danilo D Cocchiarella Fabienne F Magnani Zulma Z Ciceri Fabio F Ambrosi Alessandro A von Kalle Christof C Bushman Frederic D FD Bonini Chiara C Schmidt Manfred M Mavilio Fulvio F Recchia Alessandra A
PloS one 20101222 12
The infusion of donor lymphocytes transduced with a retroviral vector expressing the HSV-TK suicide gene in patients undergoing hematopoietic stem cell transplantation for leukemia/lymphoma promotes immune reconstitution and prevents infections and graft-versus-host disease. Analysis of the clonal dynamics of genetically modified lymphocytes in vivo is of crucial importance to understand the potential genotoxic risk of this therapeutic approach. We used linear amplification-mediated PCR and pyro ...[more]