Ontology highlight
ABSTRACT:
SUBMITTER: Tucker PK
PROVIDER: S-EPMC3008967 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Tucker Philippa K PK Evans Iwan R IR Wood Will W
Disease models & mechanisms 20101102 1
It is seldom the primary tumour that proves fatal in cancer, with metastasis the fundamental pathological process for disease progression. Upregulation of Mena, a member of the evolutionarily conserved Ena/VASP family of actin cytoskeletal regulators, promotes metastasis and invasive motility of breast cancer cells in vivo. To complement in vitro studies of Ena/VASP function in fibroblasts, we manipulated levels of Ena, the Drosophila homologue of Mena, in migrating embryonic macrophages (haemoc ...[more]