Ontology highlight
ABSTRACT:
SUBMITTER: Liu G
PROVIDER: S-EPMC3009677 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Liu Guang G Ou Hong-Yu HY Wang Tao T Li Li L Tan Huarong H Zhou Xiufen X Rajakumar Kumar K Deng Zixin Z He Xinyi X
PLoS genetics 20101223 12
Many taxonomically diverse prokaryotes enzymatically modify their DNA by replacing a non-bridging oxygen with a sulfur atom at specific sequences. The biological implications of this DNA S-modification (phosphorothioation) were unknown. We observed that simultaneous expression of the dndA-E gene cluster from Streptomyces lividans 66, which is responsible for the DNA S-modification, and the putative Streptomyces coelicolor A(3)2 Type IV methyl-dependent restriction endonuclease ScoA3McrA (Sco4631 ...[more]