Ontology highlight
ABSTRACT:
SUBMITTER: Cai M
PROVIDER: S-EPMC3009736 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Cai Mengli M Huang Ying Y Craigie Robert R Clore G Marius GM
PloS one 20101223 12
HIV-1 matrix (MA) is a multifunctional protein that is synthesized as a polyprotein that is cleaved by protease during viral maturation. MA contains a cluster of basic residues whose role is controversial. Proposed functions include membrane anchoring, facilitating viral assembly, and directing nuclear import of the viral DNA. Since MA has been reported to be a component of the preintegration complex (PIC), we have used NMR to probe its interaction with other PIC components. We show that MA inte ...[more]