Unknown

Dataset Information

0

Effects of HEPA air cleaners on unscheduled asthma visits and asthma symptoms for children exposed to secondhand tobacco smoke.


ABSTRACT: The goal was to test the effects of high-efficiency, particulate-arresting (HEPA) air cleaners on unscheduled asthma visits and symptoms among children with asthma exposed to secondhand smoke.We enrolled 225 eligible children who were 6 to 12 years of age, had physician-diagnosed asthma, and were exposed to ?5 cigarettes per day. We conducted a double-blind, randomized trial. Children were assigned randomly to receive 2 active or inactive HEPA air cleaners.Of 225 enrolled children, 110 (49%) were assigned to the intervention group and 115 (51%) to the control group; 215 (95%) completed the trial. During the trial, there were 42 fewer unscheduled asthma visits among children in the intervention group (18.5% [95% confidence interval: 1.25%-82.75%]; P = .043), compared with those in the control group, after adjustment for baseline differences. There was a significant difference in the reductions of levels of particles of >0.3 ?m according to group assignment; there was a 25% reduction in particle levels in the intervention group, compared with a 5% reduction in the control group (P = .026). There were no significant differences in parent-reported asthma symptoms, exhaled nitric-oxide levels, air nicotine levels, or cotinine levels according to group assignment.These results hold promise for using HEPA air cleaners as part of a multifaceted strategy to reduce asthma morbidity, but further research is necessary before they can be recommended routinely for the medical management of asthma.

SUBMITTER: Lanphear BP 

PROVIDER: S-EPMC3010094 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Effects of HEPA air cleaners on unscheduled asthma visits and asthma symptoms for children exposed to secondhand tobacco smoke.

Lanphear Bruce P BP   Hornung Richard W RW   Khoury Jane J   Yolton Kimberly K   Lierl Michelle M   Kalkbrenner Amy A  

Pediatrics 20101213 1


<h4>Objective</h4>The goal was to test the effects of high-efficiency, particulate-arresting (HEPA) air cleaners on unscheduled asthma visits and symptoms among children with asthma exposed to secondhand smoke.<h4>Methods</h4>We enrolled 225 eligible children who were 6 to 12 years of age, had physician-diagnosed asthma, and were exposed to ≥5 cigarettes per day. We conducted a double-blind, randomized trial. Children were assigned randomly to receive 2 active or inactive HEPA air cleaners.<h4>R  ...[more]

Similar Datasets

| S-EPMC6413330 | biostudies-literature
| S-EPMC5896480 | biostudies-literature
| S-EPMC6377972 | biostudies-literature
| S-EPMC2722845 | biostudies-literature
| S-EPMC11342744 | biostudies-literature
| S-EPMC2543006 | biostudies-literature
| S-EPMC3499331 | biostudies-literature
| S-EPMC6472795 | biostudies-literature
| S-EPMC7078760 | biostudies-literature
| S-EPMC7967984 | biostudies-literature