Ontology highlight
ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC3010190 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Liu Jialu J Xu Ji J Gu Sumin S Nicholson Bruce J BJ Jiang Jean X JX
Journal of cell science 20101220 Pt 2
Both connexin 50 (Cx50) and aquaporin 0 (AQP0) have important roles in lens development and homeostasis, and their mutations are associated with human congenital cataracts. We have previously shown that Cx50 directly interacts with AQP0. Here, we demonstrate the importance of the Cx50 intracellular loop (IL) domain in mediating the interaction with AQP0 in the lens in vivo. AQP0 significantly increased (~20-30%) the intercellular coupling and conductance of Cx50 gap junctions. However, this incr ...[more]