Ontology highlight
ABSTRACT:
SUBMITTER: Ghosh HS
PROVIDER: S-EPMC3010277 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Immunity 20101209 6
The interferon-producing plasmacytoid dendritic cells (pDCs) share common progenitors with antigen-presenting classical dendritic cells (cDCs), yet they possess distinct morphology and molecular features resembling those of lymphocytes. It is unclear whether the unique cell fate of pDCs is actively maintained in the steady state. We report that the deletion of transcription factor E2-2 from mature peripheral pDCs caused their spontaneous differentiation into cells with cDC properties. This inclu ...[more]