α-Lipoic acid protects diabetic apolipoprotein E-deficient mice from nephropathy.

ABSTRACT:

Aim

Both hyperglycemia and hyperlipidemia increase oxidative stress and contribute to the development of diabetic nephropathy (DN). We investigated the effects of α-lipoic acid, a natural antioxidant and a cofactor in the multienzyme complexes, on the development of DN in diabetic apolipoprotein E-deficient mice.

Methods

Twelve-week-old male apoE-/- mice on C57BL/6J genetic background were made diabetic with injections of streptozotocin (STZ). STZ-treated diabetic apoE-/- mice and non-diabetic control were fed with a synthetic high-fat (HF) diet with or without lipoic acid (LA) supplementation. Multiple parameters including plasma glucose, cholesterol, oxidative stress markers, cytokines, and kidney cortex gene expression, and glomerular morphology were evaluated.

Results

SUBMITTER: Yi X 

PROVIDER: S-EPMC3010318 | biostudies-literature | 2011 May-Jun

REPOSITORIES: biostudies-literature