Ontology highlight
ABSTRACT:
SUBMITTER: Kamboh MI
PROVIDER: S-EPMC3010357 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Kamboh M Ilyas MI Minster Ryan L RL Demirci F Yesim FY Ganguli Mary M Dekosky Steven T ST Lopez Oscar L OL Barmada M Michael MM
Neurobiology of aging 20100608 3
Two recent large genome-wide association studies have reported significant associations in the CLU (APOJ), CR1, and PICALM genes with the risk of Alzheimer's disease (AD). In order to replicate these findings, we examined 7 single nucleotide polymorphisms (SNPs) most significantly implicated by these studies in a large case-control sample comprising 2707 individuals. Principle components analysis revealed no population substructure in our sample. While no association was observed with CR1 SNPs ( ...[more]