Ontology highlight
ABSTRACT:
SUBMITTER: Charbonneau N
PROVIDER: S-EPMC3010362 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Cancer biology & therapy 20090730 14
The MutS (MSH) and MutL (MLH) homologs are conserved proteins that function in mismatch repair (MMR) and meiosis. We examined mRNA and protein expression of hMLH3 compared to other human MSH and MLH in a panel of human tissues and the HeLa cell line. Quantitative PCR suggests that MSH and MLH transcripts are expressed ubiquitously. hMLH3 mRNA is present at low levels in numerous tissues. Protein expression appears to correlate with a threshold of mRNA expression with hMLH3 present at high levels ...[more]