Ontology highlight
ABSTRACT:
SUBMITTER: Moyle PM
PROVIDER: S-EPMC3010531 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20101022 45
ADP-ribosylation is an important post-translational modification involved in processes including cellular replication, DNA repair, and cell death. Despite these roles, the functions of ADP-ribosylation, in particular mono-ADP-ribosylation, remain poorly understood. The development of a technique to generate large amounts of site-specific, ADP-ribosylated peptides would provide a useful tool for deconvoluting the biochemical roles of ADP-ribosylation. Here we demonstrate that synthetic histone H2 ...[more]