Ontology highlight
ABSTRACT:
SUBMITTER: Gubbels Bupp MR
PROVIDER: S-EPMC3010613 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Gubbels Bupp Melanie R MR Edwards Bonnie B Guo Caiying C Wei Datsen D Chen Gang G Wong Brian B Masteller Emma E Peng Stanford L SL
European journal of immunology 20091101 11
Forkhead transcription factors play critical roles in leukocyte homeostasis. To study further the immunological functions of Foxo1, we generated mice that selectively lack Foxo1 in T cells (Foxo1(flox/flox) Lck.cre(+)conditional knockout mice (cKO)). Although thymocyte development appeared relatively normal, Foxo1 cKO mice harbored significantly increased percentages of mature single positive T cells in the thymus as compared with WT mice, yet possessed smaller lymph nodes and spleens that conta ...[more]