Ontology highlight
ABSTRACT:
SUBMITTER: Jones EL
PROVIDER: S-EPMC3010675 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Jones Emma L EL Ballard Clive G CG Prasher Vee P VP Arno Matthew M Tyrer Stephen S Moore Brian B Hanney Maria Luisa ML
International journal of Alzheimer's disease 20101220
People with Down syndrome (DS) develop Alzheimer's disease (AD) with an early age of onset. A tetranucleotide repeat, attt(5-8), in intron 7 of the amyloid precursor protein has been associated with the age of onset of AD in DS in a preliminary study. The authors examine the impact of this polymorphism in a larger cohort of individuals with DS. Adults with DS were genotyped for attt(5-8) and APOE. The results were analysed with respect to the age of onset of dementia. The presence of three copie ...[more]