Ontology highlight
ABSTRACT:
SUBMITTER: Hutchings CJ
PROVIDER: S-EPMC3011214 | biostudies-literature | 2010 Nov-Dec
REPOSITORIES: biostudies-literature
mAbs 20101101 6
G protein-coupled receptors (GPCRs) are one of the most important classes of targets for small molecule drug discovery, but many current GPCRs of interest are proving intractable to small molecule discovery and may be better approached with bio-therapeutics. GPCRs are implicated in a wide variety of diseases where antibody therapeutics are currently used. These include inflammatory diseases such as rheumatoid arthritis and Crohn disease, as well as metabolic disease and cancer. Raising antibodie ...[more]