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Recognition tunneling measurement of the conductance of DNA bases embedded in self-assembled monolayers.

ABSTRACT: The DNA bases interact strongly with gold electrodes, complicating efforts to measure the tunneling conductance through hydrogen-bonded Watson Crick base pairs. When bases are embedded in a self-assembled alkane-thiol monolayer to minimize these interactions, new features appear in the tunneling data. These new features track the predictions of density-functional calculations quite well, suggesting that they reflect tunnel conductance through hydrogen-bonded base pairs.

SUBMITTER: Huang S

PROVIDER: S-EPMC3011824 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature

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Recognition tunneling measurement of the conductance of DNA bases embedded in self-assembled monolayers.

Huang Shuo S Chang Shuai S He Jin J Zhang Peiming P Liang Feng F Tuchband Michael M Li Shengqing S Lindsay Stuart S

The journal of physical chemistry. C, Nanomaterials and interfaces 20101201 48

The DNA bases interact strongly with gold electrodes, complicating efforts to measure the tunneling conductance through hydrogen-bonded Watson Crick base pairs. When bases are embedded in a self-assembled alkane-thiol monolayer to minimize these interactions, new features appear in the tunneling data. These new features track the predictions of density-functional calculations quite well, suggesting that they reflect tunnel conductance through hydrogen-bonded base pairs. ...[more]

PMID: 21197382

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