Ontology highlight
ABSTRACT:
SUBMITTER: Mizuno H
PROVIDER: S-EPMC3012457 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Mizuno Hideaki H Spike Benjamin T BT Wahl Geoffrey M GM Levine Arnold J AJ
Proceedings of the National Academy of Sciences of the United States of America 20101213 52
Breast cancer comprises a heterogeneous set of diseases distinguishable from one another by pathologic presentation and molecular signatures. However, each breast cancer subtype is also heterogeneous. Some of the heterogeneity may be attributable to genetic instability, but recent data emphasize that developmental plasticity may also contribute. The p53 tumor suppressor could constitute a nodal control point underlying both sources of heterogeneity because it is frequently inactivated during mal ...[more]