Longitudinal evidence for diminished frontal cortex function in aging.
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ABSTRACT:
SUBMITTER: Nyberg L
PROVIDER: S-EPMC3012514 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Publications
Longitudinal evidence for diminished frontal cortex function in aging.
Nyberg Lars L Salami Alireza A Andersson Mikael M Eriksson Johan J Kalpouzos Grégoria G Kauppi Karolina K Lind Johanna J Pudas Sara S Persson Jonas J Nilsson Lars-Göran LG
Proceedings of the National Academy of Sciences of the United States of America 20101214 52
Cross-sectional estimates of age-related changes in brain structure and function were compared with 6-y longitudinal estimates. The results indicated increased sensitivity of the longitudinal approach as well as qualitative differences. Critically, the cross-sectional analyses were suggestive of age-related frontal overrecruitment, whereas the longitudinal analyses revealed frontal underrecruitment with advancing age. The cross-sectional observation of overrecruitment reflected a select elderly ...[more]
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