Ontology highlight
ABSTRACT:
SUBMITTER: Wingard JR
PROVIDER: S-EPMC3012532 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Wingard John R JR Carter Shelly L SL Walsh Thomas J TJ Kurtzberg Joanne J Small Trudy N TN Baden Lindsey R LR Gersten Iris D ID Mendizabal Adam M AM Leather Helen L HL Confer Dennis L DL Maziarz Richard T RT Stadtmauer Edward A EA Bolaños-Meade Javier J Brown Janice J Dipersio John F JF Boeckh Michael M Marr Kieren A KA
Blood 20100908 24
Invasive fungal infection (IFI) is a serious threat after allogeneic hematopoietic cell transplant (HCT). This multicenter, randomized, double-blind trial compared fluconazole (N = 295) versus voriconazole (N = 305) for the prevention of IFI in the context of a structured fungal screening program. Patients undergoing myeloablative allogeneic HCT were randomized before HCT to receive study drugs for 100 days, or for 180 days in higher-risk patients. Serum galactomannan was assayed twice weekly fo ...[more]