Heme oxygenase system in hepatic ischemia-reperfusion injury.
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ABSTRACT:
SUBMITTER: Richards JA
PROVIDER: S-EPMC3012573 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Publications
Heme oxygenase system in hepatic ischemia-reperfusion injury.
Richards James A JA Wigmore Stephen J SJ Devey Luke R LR
World journal of gastroenterology 20101201 48
Hepatic ischemia-reperfusion injury (IRI) limits access to transplantation. Heme oxygenase-1 (HO-1) is a powerful antioxidant enzyme which degrades free heme into biliverdin, free iron and carbon monoxide. HO-1 and its metabolites have the ability to modulate a wide variety of inflammatory disorders including hepatic IRI. Mechanisms of this protective effect include reduction of oxygen free radicals, alteration of macrophage and T cell phenotype. Further work is required to understand the physio ...[more]
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