Ontology highlight
ABSTRACT:
SUBMITTER: Huang QQ
PROVIDER: S-EPMC3012591 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Huang Qi-Quan QQ Perlman Harris H Huang Zan Z Birkett Robert R Kan Lixin L Agrawal Hemant H Misharin Alexander A Gurbuxani Sandeep S Crispino John D JD Pope Richard M RM
Blood 20100819 23
FLIP is a well-established suppressor of death receptor-mediated apoptosis. To define its essential in vivo role in myeloid cells, we generated and characterized mice with Flip conditionally deleted in the myeloid lineage. Myeloid specific Flip-deficient mice exhibited growth retardation, premature death, and splenomegaly with altered architecture and extramedullary hematopoiesis. They also displayed a dramatic increase of circulating neutrophils and multiorgan neutrophil infiltration. In contra ...[more]