Control of pancreas and liver gene expression by HNF transcription factors.
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ABSTRACT:
SUBMITTER: Odom DT
PROVIDER: S-EPMC3012624 | biostudies-literature | 2004 Feb
REPOSITORIES: biostudies-literature
Publications
Control of pancreas and liver gene expression by HNF transcription factors.
Odom Duncan T DT Zizlsperger Nora N Gordon D Benjamin DB Bell George W GW Rinaldi Nicola J NJ Murray Heather L HL Volkert Tom L TL Schreiber Jörg J Rolfe P Alexander PA Gifford David K DK Fraenkel Ernest E Bell Graeme I GI Young Richard A RA
Science (New York, N.Y.) 20040201 5662
The transcriptional regulatory networks that specify and maintain human tissue diversity are largely uncharted. To gain insight into this circuitry, we used chromatin immunoprecipitation combined with promoter microarrays to identify systematically the genes occupied by the transcriptional regulators HNF1alpha, HNF4alpha, and HNF6, together with RNA polymerase II, in human liver and pancreatic islets. We identified tissue-specific regulatory circuits formed by HNF1alpha, HNF4alpha, and HNF6 with ...[more]
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