Ontology highlight
ABSTRACT:
SUBMITTER: Grassian AR
PROVIDER: S-EPMC3013038 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Grassian Alexandra R AR Schafer Zachary T ZT Brugge Joan S JS
The Journal of biological chemistry 20101018 1
Epithelial cells are dependent on extracellular matrix (ECM) attachment for maintenance of metabolic activity and suppression of apoptosis. Here we show that loss of ECM attachment causes down-regulation of epidermal growth factor receptor (EGFR) and β1 integrin protein and mRNA expression and that ErbB2, which is amplified in 25% of breast tumors, reverses these effects of ECM deprivation. ErbB2 rescue of β1 integrin mRNA and protein in suspended cells is dependent on EGFR, however, the rescue ...[more]