Ontology highlight
ABSTRACT:
SUBMITTER: Seemanapalli SV
PROVIDER: S-EPMC3013124 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Seemanapalli Sunita V SV Xu Qilong Q McShan Kristy K Liang Fang Ting FT
PloS one 20101231 12
<h4>Background</h4>The Lyme disease spirochete Borrelia burgdorferi dramatically upregulates outer surface protein C (OspC) in response to fresh bloodmeal during transmission from the tick vector to a mammal, and abundantly produces the antigen during early infection. As OspC is an effective immune target, to evade the immune system B. burgdorferi downregulates the antigen once the anti-OspC humoral response has developed, suggesting an important role for OspC during early infection.<h4>Methodol ...[more]