Ontology highlight
ABSTRACT:
SUBMITTER: Franklin S
PROVIDER: S-EPMC3013444 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Franklin Sarah S Zhang Michael J MJ Chen Haodong H Paulsson Anna K AK Mitchell-Jordan Scherise A SA Li Yifeng Y Ping Peipei P Vondriska Thomas M TM
Molecular & cellular proteomics : MCP 20100831 1
As host to the genome, the nucleus plays a critical role as modulator of cellular phenotype. To understand the totality of proteins that regulate this organelle, we used proteomics to characterize the components of the cardiac nucleus. Following purification, cardiac nuclei were fractionated into biologically relevant fractions including acid-soluble proteins, chromatin-bound molecules and nucleoplasmic proteins. These distinct subproteomes were characterized by liquid chromatography-tandem MS. ...[more]