Uncovering the human methyltransferasome.
Ontology highlight
ABSTRACT:
SUBMITTER: Petrossian TC
PROVIDER: S-EPMC3013446 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Publications
Uncovering the human methyltransferasome.
Petrossian Tanya C TC Clarke Steven G SG
Molecular & cellular proteomics : MCP 20101007 1
We present a comprehensive analysis of the human methyltransferasome. Primary sequences, predicted secondary structures, and solved crystal structures of known methyltransferases were analyzed by hidden Markov models, Fisher-based statistical matrices, and fold recognition prediction-based threading algorithms to create a model, or profile, of each methyltransferase superfamily. These profiles were used to scan the human proteome database and detect novel methyltransferases. 208 proteins in the ...[more]
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