Ontology highlight
ABSTRACT:
SUBMITTER: Wu F
PROVIDER: S-EPMC3013520 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Wu Fiona F Saleem Moin A MA Kampik Nicole B NB Satchwell Timothy J TJ Williamson Rosalind C RC Blattner Simone M SM Ni Lan L Toth Tibor T White Graham G Young Mark T MT Parker Mark D MD Alper Seth L SL Wagner Carsten A CA Toye Ashley M AM
Journal of the American Society of Nephrology : JASN 20100624 9
The central role of the multifunctional protein nephrin within the macromolecular complex forming the glomerular slit diaphragm is well established, but the mechanisms linking the slit diaphragm to the cytoskeleton and to the signaling pathways involved in maintaining the integrity of the glomerular filter remain incompletely understood. Here, we report that nephrin interacts with the bicarbonate/chloride transporter kidney anion exchanger 1 (kAE1), detected by yeast two-hybrid assay and confirm ...[more]