Ontology highlight
ABSTRACT:
SUBMITTER: Zhai Q
PROVIDER: S-EPMC3014167 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Zhai Qianting Q Landesman Michael B MB Robinson Howard H Sundquist Wesley I WI Hill Christopher P CP
Journal of virology 20101020 1
Retroviral Gag proteins contain short late-domain motifs that recruit cellular ESCRT pathway proteins to facilitate virus budding. ALIX-binding late domains often contain the core consensus sequence YPX(n)L (where X(n) can vary in sequence and length). However, some simian immunodeficiency virus (SIV) Gag proteins lack this consensus sequence, yet still bind ALIX. We mapped divergent, ALIX-binding late domains within the p6(Gag) proteins of SIV(mac239) ((40)SREKPYKEVTEDLLHLNSLF(59)) and SIV(agmT ...[more]