Ontology highlight
ABSTRACT:
SUBMITTER: Zhang F
PROVIDER: S-EPMC3014266 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Zhang Fan F Tagen Michael M Throm Stacy S Mallari Jeremy J Miller Laura L Guy R Kiplin RK Dyer Michael A MA Williams Richard T RT Roussel Martine F MF Nemeth Katie K Zhu Fangyi F Zhang Jiakun J Lu Min M Panetta John C JC Boulos Nidal N Stewart Clinton F CF
Drug metabolism and disposition: the biological fate of chemicals 20101014 1
Nutlin-3a is an MDM2 inhibitor that is under investigation in preclinical models for a variety of pediatric malignancies, including retinoblastoma, rhabdomyosarcoma, neuroblastoma, and leukemia. We used physiologically based pharmacokinetic (PBPK) modeling to characterize the disposition of nutlin-3a in the mouse. Plasma protein binding and blood partitioning were assessed by in vitro studies. After intravenous (10 and 20 mg/kg) and oral (50, 100, and 200 mg/kg) dosing, tissue concentrations of ...[more]