Ontology highlight
ABSTRACT:
SUBMITTER: Cong H
PROVIDER: S-EPMC3014376 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Cong Hua H Mui Ernest J EJ Witola William H WH Sidney John J Alexander Jeff J Sette Alessandro A Maewal Ajesh A McLeod Rima R
Vaccine 20101121 4
The ideal vaccine to protect against toxoplasmosis in humans would include antigens that elicit a protective T helper cell type 1 immune response, and generate long-lived IFN-γ-producing CD8(+) T cells. Herein, we utilized a predictive algorithm to identify candidate HLA-A02 supertype epitopes from Toxoplasma gondii proteins. Thirteen peptides elicited production of IFN-γ from PBMC of HLA-A02 supertype persons seropositive for T. gondii infection but not from seronegative controls. These peptide ...[more]