Detecting cancer gene networks characterized by recurrent genomic alterations in a population.
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ABSTRACT:
SUBMITTER: Efroni S
PROVIDER: S-EPMC3014942 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
Detecting cancer gene networks characterized by recurrent genomic alterations in a population.
Efroni Sol S Ben-Hamo Rotem R Edmonson Michael M Greenblum Sharon S Schaefer Carl F CF Buetow Kenneth H KH
PloS one 20110104 1
High resolution, system-wide characterizations have demonstrated the capacity to identify genomic regions that undergo genomic aberrations. Such research efforts often aim at associating these regions with disease etiology and outcome. Identifying the corresponding biologic processes that are responsible for disease and its outcome remains challenging. Using novel analytic methods that utilize the structure of biologic networks, we are able to identify the specific networks that are highly signi ...[more]
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