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The vertebrate primary cilium in development, homeostasis, and disease.

ABSTRACT: Cilia are complex structures that have garnered interest because of their roles in vertebrate development and their involvement in human genetic disorders. In contrast to multicellular invertebrates in which cilia are restricted to specific cell types, these organelles are found almost ubiquitously in vertebrate cells, where they serve a diverse set of signaling functions. Here, we highlight properties of vertebrate cilia, with particular emphasis on their relationship with other subcellular structures, and explore the physiological consequences of ciliary dysfunction.

SUBMITTER: Gerdes JM

PROVIDER: S-EPMC3016012 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature

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The vertebrate primary cilium in development, homeostasis, and disease.

Gerdes Jantje M JM Davis Erica E EE Katsanis Nicholas N

Cell 20090401 1

Cilia are complex structures that have garnered interest because of their roles in vertebrate development and their involvement in human genetic disorders. In contrast to multicellular invertebrates in which cilia are restricted to specific cell types, these organelles are found almost ubiquitously in vertebrate cells, where they serve a diverse set of signaling functions. Here, we highlight properties of vertebrate cilia, with particular emphasis on their relationship with other subcellular str ...[more]

PMID: 19345185

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