Ontology highlight
ABSTRACT:
SUBMITTER: Gordon L
PROVIDER: S-EPMC3016086 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Gordon Laura L Mansh Matthew M Kinsman Helen H Morris Andrea R AR
Developmental dynamics : an official publication of the American Association of Anatomists 20101101 11
The role of classic morphogens such as Sonic hedgehog (Shh) as axon guidance cues has been reported in a variety of vertebrate organisms (Charron and Tessier-Lavigne [2005] Development 132:2251-2262). In this work, we provide the first evidence that Xenopus sonic hedgehog (Xshh) signaling is involved in guiding retinal ganglion cell (RGC) axons along the optic tract. Xshh is expressed in the brain during retinal axon extension, adjacent to these axons in the ventral diencephalon. Retinal axons t ...[more]