Ontology highlight
ABSTRACT:
SUBMITTER: Srinivasan K
PROVIDER: S-EPMC3016226 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Srinivasan Karpagam K Roosa Jason J Olsen Olav O Lee Soung-Hun SH Bredt David S DS McConnell Susan K SK
Development (Cambridge, England) 20080409 10
Apicobasal polarity plays an important role in regulating asymmetric cell divisions by neural progenitor cells (NPCs) in invertebrates, but the role of polarity in mammalian NPCs is poorly understood. Here, we characterize the function of the PDZ domain protein MALS-3 in the developing cerebral cortex. We find that MALS-3 is localized to the apical domain of NPCs. Mice lacking all three MALS genes fail to localize the polarity proteins PATJ and PALS1 apically in NPCs, whereas the formation and m ...[more]