Positive Darwinian selection drives the evolution of several female reproductive proteins in mammals.
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ABSTRACT:
SUBMITTER: Swanson WJ
PROVIDER: S-EPMC30168 | biostudies-literature | 2001 Feb
REPOSITORIES: biostudies-literature
Publications
Positive Darwinian selection drives the evolution of several female reproductive proteins in mammals.
Swanson W J WJ Yang Z Z Wolfner M F MF Aquadro C F CF
Proceedings of the National Academy of Sciences of the United States of America 20010220 5
Rapid evolution driven by positive Darwinian selection is a recurrent theme in male reproductive protein evolution. In contrast, positive selection has never been demonstrated for female reproductive proteins. Here, we perform phylogeny-based tests on three female mammalian fertilization proteins and demonstrate positive selection promoting their divergence. Two of these female fertilization proteins, the zona pellucida glycoproteins ZP2 and ZP3, are part of the mammalian egg coat. Several sites ...[more]
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