A comprehensive model of the spatio-temporal stem cell and tissue organisation in the intestinal crypt.
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ABSTRACT:
SUBMITTER: Buske P
PROVIDER: S-EPMC3017108 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
A comprehensive model of the spatio-temporal stem cell and tissue organisation in the intestinal crypt.
Buske Peter P Galle Jörg J Barker Nick N Aust Gabriela G Clevers Hans H Loeffler Markus M
PLoS computational biology 20110106 1
We introduce a novel dynamic model of stem cell and tissue organisation in murine intestinal crypts. Integrating the molecular, cellular and tissue level of description, this model links a broad spectrum of experimental observations encompassing spatially confined cell proliferation, directed cell migration, multiple cell lineage decisions and clonal competition.Using computational simulations we demonstrate that the model is capable of quantitatively describing and predicting the dynamic behavi ...[more]
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